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Huntington's disease, chorea, or disorder (HD), is a progressive neurodegenerative genetic disorder, which affects muscle coordination and leads to cognitive decline and dementia. It typically becomes noticeable in middle age.

Signs and symptoms Huntington's disease

Symptoms of Huntington's disease commonly become noticeable between the ages of 35 and 44 years, but they can begin at any age from infancy, In the early stages, there are subtle changes in personality, cognition, or physical skills, The most characteristic initial physical symptoms are jerky, random, and uncontrollable movements called chorea, These minor motor abnormalities usually precede more obvious signs of motor dysfunction by at least three years,

Common consequences are physical instability, abnormal facial expression, and difficulties chewing, swallowing and speaking.

Huntington's disease Diagnosis

How far the disease has progressed can be measured using the unified Huntington's disease rating scale which provides an overall rating system based on motor, behavioral, cognitive, and functional assessments. Medical imaging, such as computerized tomography (CT) and magnetic resonance imaging (MRI), only shows visible cerebral atrophy in the advanced stages of the disease. Functional neuroimaging techniques such as fMRI and PET can show changes in brain activity before the onset of physical symptoms.
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